Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mapk3  mitogen-activated protein kinase 3   (Synonyms: Erk1, Erk-1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3)
Results	Reference
1	J:172398 Ackermann J, Ashton G, Lyons S, James D, Hornung JP, Jones N, Breitwieser W, Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development. PLoS One. 2011;6(4):e19090
1	J:315767 Ahn SY, Kim Y, Kim ST, Swat W, Miner JH, Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development. J Am Soc Nephrol. 2013 Jun;24(7):1127-38
1	J:258488 Aoidi R, Maltais A, Charron J, Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect. Sci Signal. 2016 Jan 26;9(412):ra9
1	J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
1	J:214083 Boucherat O, Nadeau V, Berube-Simard FA, Charron J, Jeannotte L, Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development. 2014 Aug;141(16):3197-211
1	J:127546 Brinkmeier ML, Potok MA, Davis SW, Camper SA, TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007 Nov 15;311(2):396-407
1	J:159104 Cai Z, Feng GS, Zhang X, Temporal requirement of the protein TyrosinePhosphatase Shp2 in establishing the neuronal fatein early retinal development. J Neurosci. 2010 Mar 17;30(11):4110-9
1	J:233810 Chan WK, Howe K, Clegg JM, Guimond SE, Price DJ, Turnbull JE, Pratt T, 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS One. 2015;10(6):e0130147
1	J:273460 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X, Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 Jan 23;7:e32586
1	J:173576 Di Giovanni V, Alday A, Chi L, Mishina Y, Rosenblum ND, Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm. Development. 2011 Jul;138(13):2717-27
1	J:273024 DiNuoscio G, Atit RP, Wnt/beta-catenin signaling in the mouse embryonic cranial mesenchyme is required to sustain the emerging differentiated meningeal layers. Genesis. 2019 Jan;57(1):e23279
1	J:213791 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR, Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28
1	J:159106 Faedo A, Borello U, Rubenstein JL, Repression of fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times. J Neurosci. 2010 Mar 17;30(11):4015-23
1	J:237068 Fatima A, Wang Y, Uchida Y, Norden P, Liu T, Culver A, Dietz WH, Culver F, Millay M, Mukouyama YS, Kume T, Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation. J Clin Invest. 2016 Jul 01;126(7):2437-51
1	J:171201 Furusho M, Kaga Y, Ishii A, Hebert JM, Bansal R, Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain. J Neurosci. 2011 Mar 30;31(13):5055-66
1	J:136180 Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R, Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309
1	J:77351 Goudreau G, Petrou P, Reneker LW, Graw J, Loster J, Gruss P, Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24
1	J:222425 Harada M, Omori A, Nakahara C, Nakagata N, Akita K, Yamada G, Tissue-specific roles of FGF signaling in external genitalia development. Dev Dyn. 2015 Jun;244(6):759-73
1	J:241998 Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, Gonzalez-Meljem JM, Apps JR, Virasami A, Thavaraj S, Gutteridge A, Forshew T, Marais R, Brandner S, Jacques TS, Andoniadou CL, Martinez-Barbera JP, MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma. Development. 2017 Jun 15;144(12):2141-2152
1	J:243870 He H, Huang M, Sun S, Wu Y, Lin X, Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development. PLoS Genet. 2017 Aug;13(8):e1006992
1*	J:320347 Jiang K, Tang Z, Li J, Wang F, Tang N, Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification. Sci Rep. 2018 Sep 25;8(1):14344
1	J:181400 Kuracha MR, Burgess D, Siefker E, Cooper JT, Licht JD, Robinson ML, Govindarajan V, Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6887-97
1	J:182759 Lahti L, Peltopuro P, Piepponen TP, Partanen J, Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain. Development. 2012 Mar;139(5):894-905
1	J:168023 Lahti L, Saarimaki-Vire J, Rita H, Partanen J, FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors. Dev Biol. 2011 Jan 15;349(2):270-82
1	J:310318 Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X, Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 1;127(Pt 3):571-82
1	J:217046 Magnani D, Hasenpusch-Theil K, Benadiba C, Yu T, Basson MA, Price DJ, Lebrand C, Theil T, Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. Cereb Cortex. 2014 Jan;24(1):186-98
1	J:243772 Mamo TM, Wittern AB, Kleppa MJ, Bohnenpoll T, Weiss AC, Kispert A, BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter. Hum Mol Genet. 2017 Sep 15;26(18):3553-3563
1	J:321503 Meuser M, Deuper L, Rudat C, Aydogdu N, Thiesler H, Zarnovican P, Hildebrandt H, Trowe MO, Kispert A, FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
1	J:147279 Nadeau V, Guillemette S, Belanger LF, Jacob O, Roy S, Charron J, Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation. Development. 2009 Apr;136(8):1363-74
1	J:228583 Nandadasa S, Nelson CM, Apte SS, ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16;11(10):1519-28
1	J:235677 Noraz N, Jaaoini I, Charoy C, Watrin C, Chounlamountri N, Benon A, Malleval C, Boudin H, Honnorat J, Castellani V, Pellier-Monnin V, Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway. Development. 2016 Jun 15;143(12):2183-93
1	J:311929 Okubo Y, Ohtake F, Igarashi K, Yasuhiko Y, Hirabayashi Y, Saga Y, Kanno J, Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways. Development. 2021 Oct 1;148(19):dev193664
1	J:158679 Pan Y, Carbe C, Powers A, Feng GS, Zhang X, Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development. 2010 Apr;137(7):1085-93
1	J:130571 Pan Y, Carbe C, Powers A, Zhang EE, Esko JD, Grobe K, Feng GS, Zhang X, Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development. 2008 Jan;135(2):301-10
1	J:239772 Parada C, Han D, Grimaldi A, Sarrion P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y, Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 01;142(21):3734-45
1	J:236785 Pathania M, Wang Y, Simirskii VN, Duncan MK, beta1-integrin controls cell fate specification in early lens development. Differentiation. 2016 Oct - Nov;92(4):133-147
1	J:191071 Petzold KM, Naumann H, Spagnoli FM, Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas. Development. 2013 Jan 1;140(1):126-35
1	J:99391 Shu W, Guttentag S, Wang Z, Andl T, Ballard P, Lu MM, Piccolo S, Birchmeier W, Whitsett JA, Millar SE, Morrisey EE, Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol. 2005 Jul 1;283(1):226-39
1	J:223201 Song R, Preston G, Ichihara A, Yosypiv IV, Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. PLoS One. 2013;8(5):e63835
1	J:174194 Tang N, Marshall WF, McMahon M, Metzger RJ, Martin GR, Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science. 2011 Jul 15;333(6040):342-5
1	J:306142 Tian A, Wang S, Wang H, Li N, Liu H, Zhou H, Chen X, Liu X, Deng J, Xiao J, Liu C, Over-expression of Fgf8 in cardiac neural crest cells leads to persistent truncus arteriosus. J Mol Histol. 2021 Apr;52(2):351-361
1	J:202753 Uesaka T, Nagashimada M, Enomoto H, GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. J Neurosci. 2013 Oct 9;33(41):16372-82
1	J:317033 Xie C, Abrams SR, Herranz-Perez V, Garcia-Verdugo JM, Reiter JF, Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity. Dev Cell. 2021 Dec 20;56(24):3334-3348.e6
1	J:295961 Yabut OR, Ng HX, Yoon K, Arela JC, Ngo T, Pleasure SJ, The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling. J Neurosci. 2020 Sep 2;40(36):6872-6887
1	J:137691 Yin Y, White AC, Huh SH, Hilton MJ, Kanazawa H, Long F, Ornitz DM, An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol. 2008 Jul 15;319(2):426-36
1	J:217590 Yuan G, Yang G, Zheng Y, Zhu X, Chen Z, Zhang Z, Chen Y, The non-canonical BMP and Wnt/beta-catenin signaling pathways orchestrate early tooth development. Development. 2015 Jan 1;142(1):128-39
1*	J:136711 Zhao H, Yang T, Madakashira BP, Thiels CA, Bechtle CA, Garcia CM, Zhang H, Yu K, Ornitz DM, Beebe DC, Robinson ML, Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008 Jun 15;318(2):276-88